Administration in Nitrofen-Induced Congenital Diaphragmatic Hernia Ghrelin Expression in Human and Rat Fetal Lungs and the Effect of Ghrelin
نویسندگان
چکیده
287:2885-2890, 2004. First published Aug 26, 2004; Am J Physiol Heart Circ Physiol Leite-Moreira Brandão-Nogueira, Antónia Teles, José M. Fortunato and Adelino F. Maria J. Baptista, André P. Lourenço, Sílvia Marta Oliveira, Ana Tiago Henriques-Coelho, Jorge Correia-Pinto, Roberto Roncon-Albuquerque, Jr, monocrotaline-induced pulmonary hypertension effects of its exogenous administration in Endogenous production of ghrelin and beneficial
منابع مشابه
Effect of dexamethasone on endothelial nitric oxide synthase in experimental congenital diaphragmatic hernia.
AIMS To study the effect of prenatal glucocorticoid treatment on endothelial nitric oxide synthase (eNOS) expression in rats with congenital diaphragmatic hernia (CDH). METHODS CDH was induced in fetal rats by the maternal administration of nitrofen on day 9.5 of gestation. Dexamethasone was administered on days 18.5 and 19.5 before delivery of the fetuses on days 20.5 and 21.5. Pulmonary eNO...
متن کاملLung hypoplasia in the nitrofen model of congenital diaphragmatic hernia occurs early in development.
The teratogen nitrofen produces a congenital diaphragmatic hernia (CDH) and pulmonary hypoplasia in rodent fetuses that closely parallel observations made in humans. We hypothesized that these changes may be due to primary pulmonary hypoplasia and not herniation of the abdominal contents. Timed-pregnant rats were given nitrofen on day 9, and fetuses were harvested on days 13 through 21. Initial...
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Introduction. Vascular endothelial growth factor (VEGF), an angiogenic factor secreted by type II pneumocytes, could play a role in congenital diaphragmatic hernia (CDH) pathogenesis. Animal studies suggest that VEGF accelerates lung growth. Aim. To quantify VEGF on fetal lungs in a nitrofen rat model for CDH and to analyze the effect of tracheal occlusion (TO) in VEGF in fetal lung rats after ...
متن کاملInhibition of vascular and epithelial differentiation in murine nitrofen-induced diaphragmatic hernia.
Neonates with congenital diaphragmatic hernia (DH) die of pulmonary hypoplasia and persistent pulmonary hypertension. We used immunohistochemical localization of α-smooth muscle actin (α-SMA), platelet endothelial cell adhesion molecule (PECAM)-1, thyroid transcription factor (TTF)-1, surfactant protein (SP) A, SP-C, and competitive RT-PCR quantitation of TTF-1, SP-A, SP-C, and α-SMA mRNA expre...
متن کاملRole of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114)
Congenital diaphragmatic hernia (CDH) is a life-threatening neonatal disease that leads to lung hypoplasia and pulmonary hypertension. We recently found that maternal prenatal administration of Saireito (TJ-114) ameliorates fetal CDH in a nitrofen-induced rat model. Here, we studied the role of iron and oxidative stress in neonates of this model and in lung fibroblasts IMR90-SV in association w...
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